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Bo-Anders Jönsson

Professor

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Radiation dosimetry for indium-111-labeled anti-CEA-F(ab')2 fragments evaluated from tissue distribution in rats

Författare

  • Bo-Anders Jönsson
  • Sven-Erik Strand
  • Lena Andersson

Summary, in English

Accurate dosimetric investigations are important to be able to fulfill the ambition of radiation protection in nuclear medicine and to minimize the radiation burden to the patient. This paper presents human radiation absorbed dose estimates following an administration of an 111In-labeled anti-CEA-F(ab')2 (BW431/31) based on detailed biodistribution and elimination data in a rat model. Animals were followed from the time of injection up to 28 days after injection. A significant initial uptake of 111In in the bone marrow, 25% of injected activity, was evident after 6 hr. The kidneys showed a maximal uptake of 20% at 24 hr. At the end of the study, 27% of the activity was still retained in the whole body. The estimated humans absorbed dose to the kidneys, testes, spleen and bone marrow was 2.27, 0.80, 0.51 and 0.37 mGy MBq-1, respectively. The effective dose was estimated to 0.27 mSv MBq-1. The tissue distribution in rats was comparable to that in humans, which was confirmed by whole-body scintigrams and human biopsies

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

1992

Språk

Engelska

Sidor

1654-1660

Publikation/Tidskrift/Serie

Journal of Nuclear Medicine

Volym

33

Issue

9

Dokumenttyp

Artikel i tidskrift

Förlag

Society of Nuclear Medicine

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0161-5505