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Crister Ceberg

Professor

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3D geometric gel dosimetry verification of intraprostatic fiducial guided hypofractionated radiotherapy of prostate cancer

Författare

  • Fredrik Nordström
  • Sofie Ceberg
  • Sacha af Wetterstedt
  • Per Nilsson
  • Crister Ceberg
  • Sven Bäck

Summary, in English

This pre-study is aimed to investigate the feasibility of a normoxic polyacrylamide gel (nPAG) dosimeter with implanted gold fiducials to evaluate the geometric precision, including setup correction strategies, in the delivery of hypofractionated treatments. For this purpose a phantom consisting of three parts was constructed: (1) the patient simulating volume, providing realistic scatter conditions and weight, (2) a bottle containing the active dosimetric volume and (3) the gold fiducials and the fiducial support structure. A 6.1 Gy prostate IMRT treatment was delivered to the phantom using the sliding-window technique. The phantom was positioned prior to the treatment using the implanted fiducials and kV on-board imaging. An overlay of the 95% isosurface of the TPS calculated dose distribution and the measured dose distribution using gel showed good agreement. The clinical target volume (CTV) was well centred inside the 95% isodose surface of the measured volume. It was shown for the evaluated case that the use of on-board imaging and integrated setup correction tools could be used to compensate for a deliberately introduced offset in CTV position. The study showed that MRI based nPAG gel dosimetry can be used to verify setup correction procedures using implanted gold fiducials.

Avdelning/ar

  • Medicinsk strålningsfysik, Malmö
  • Medicinsk strålningsfysik, Lund

Publiceringsår

2010

Språk

Engelska

Publikation/Tidskrift/Serie

Journal of Physics: Conference Series

Volym

250

Dokumenttyp

Konferensbidrag

Förlag

IOP Publishing

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • 3D verification
  • radiotherapy
  • polymer gel

Conference name

IC3DDose: The 6th International Conference on 3D Radiation Dosimetry

Conference date

2010-08-22

Conference place

Hilton Head Island, South Carolina, United States

Status

Published

Forskningsgrupp

  • Medical Radiation Physics, Malmö