Crister Ceberg
Professor
Research Paper Impact of combining vitamin C with radiation therapy in human breast cancer : Does it matter?
Författare
Summary, in English
Vitamin C may impact the efficiency of radiation therapy (RT) in breast cancer. The effects of RT alone or in combination with vitamin C in SKBR3, MDA-MB-231, and MCF7 cells were compared using clonogenic assay, proliferation assay (MTT), cell cycle analysis, and Western blot. Vitamin C use was assessed in 1803 breast cancer patients 2002–2017 in relation to clinicopathological features and recurrences after RT. Vitamin C combined with RT resulted in non-significant increases in colony formation and minor differences in cell cycle arrest and expression of studied proteins, compared to RT alone. Lower vitamin C doses alone or in combination with RT, resulted in higher proliferation with MTT than higher vitamin C doses in a cell line-dependent manner. Vitamin C use was associated with lower histological grade and BMI but not recurrence risk in RT-treated patients (LogRank P = 0.54). Vitamin C impacted RT efficiency differently depending on breast cancer subtype and vitamin C concentration. Lower doses of vitamin C, achievable with oral administration, might increase breast cancer cell proliferation and decrease radiosensitivity. Despite vitamin C users having less aggressive tumors than non-users, the recurrence risk in RT-treated patients was similar in vitamin C users and non-users.
Avdelning/ar
- Avdelningen för hematologi och klinisk immunologi
- LUCC: Lunds universitets cancercentrum
- Cancerepidemiologi & strål
- Strålterapi
- Epidemiologi och farmakogenetik
- Medicinsk strålningsfysik, Lund
- Radiotherapy Physics
- Bröstcancer - prevention & intervention
- Bröstcancer
- Kirurgi, Lund
- EpiHealth: Epidemiology for Health
Publiceringsår
2022
Språk
Engelska
Sidor
439-453
Publikation/Tidskrift/Serie
Oncotarget
Volym
13
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Impact Journals
Ämne
- Cancer and Oncology
Nyckelord
- clinical outcome
- human breast cancer
- in vitro
- radiation therapy
- vitamin C
Aktiv
Published
Forskningsgrupp
- Epidemiology and pharmacogenetics
- Radiotherapy Physics
- Breast cancer prevention & intervention
ISBN/ISSN/Övrigt
- ISSN: 1949-2553