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Ceberg

Crister Ceberg

Professor

Ceberg

Research Paper Impact of combining vitamin C with radiation therapy in human breast cancer : Does it matter?

Författare

  • Somayeh Khazaei
  • Linn Nilsson
  • Gabriel Adrian
  • Helga Tryggvadottir
  • Elise Konradsson
  • Signe Borgquist
  • Karolin Isaksson
  • Crister Ceberg
  • Helena Jernström

Summary, in English

Vitamin C may impact the efficiency of radiation therapy (RT) in breast cancer. The effects of RT alone or in combination with vitamin C in SKBR3, MDA-MB-231, and MCF7 cells were compared using clonogenic assay, proliferation assay (MTT), cell cycle analysis, and Western blot. Vitamin C use was assessed in 1803 breast cancer patients 2002–2017 in relation to clinicopathological features and recurrences after RT. Vitamin C combined with RT resulted in non-significant increases in colony formation and minor differences in cell cycle arrest and expression of studied proteins, compared to RT alone. Lower vitamin C doses alone or in combination with RT, resulted in higher proliferation with MTT than higher vitamin C doses in a cell line-dependent manner. Vitamin C use was associated with lower histological grade and BMI but not recurrence risk in RT-treated patients (LogRank P = 0.54). Vitamin C impacted RT efficiency differently depending on breast cancer subtype and vitamin C concentration. Lower doses of vitamin C, achievable with oral administration, might increase breast cancer cell proliferation and decrease radiosensitivity. Despite vitamin C users having less aggressive tumors than non-users, the recurrence risk in RT-treated patients was similar in vitamin C users and non-users.

Avdelning/ar

  • Avdelningen för hematologi och transfusionsmedicin
  • LUCC: Lunds universitets cancercentrum
  • Cancerepidemiologi & strål
  • Strålterapi
  • Epidemiologi och farmakogenetik
  • Medicinsk strålningsfysik, Lund
  • Radiotherapy Physics
  • Bröstcancer - prevention & intervention
  • Bröstcancer
  • Kirurgi, Lund
  • EpiHealth: Epidemiology for Health

Publiceringsår

2022

Språk

Engelska

Sidor

439-453

Publikation/Tidskrift/Serie

Oncotarget

Volym

13

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Impact Journals

Ämne

  • Cancer and Oncology

Nyckelord

  • clinical outcome
  • human breast cancer
  • in vitro
  • radiation therapy
  • vitamin C

Status

Published

Forskningsgrupp

  • Epidemiology and pharmacogenetics
  • Radiotherapy Physics
  • Breast cancer prevention & intervention

ISBN/ISSN/Övrigt

  • ISSN: 1949-2553