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Ceberg

Crister Ceberg

Professor

Ceberg

Neutron capture imaging of 10B in tissue specimens

Författare

  • Crister Ceberg
  • Leif Salford
  • Arne Brun
  • Raphael J B Hemler
  • Bertil R Persson

Summary, in English

Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • Neurokirurgi
  • Tumörmikromiljö

Publiceringsår

1993

Språk

Engelska

Sidor

139-146

Publikation/Tidskrift/Serie

Radiotherapy and Oncology

Volym

26

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging
  • Cancer and Oncology

Nyckelord

  • BNCT
  • Glioma
  • Bio-distribution
  • Boron imaging
  • Track-films
  • Self-absorption

Aktiv

Published

ISBN/ISSN/Övrigt

  • ISSN: 1879-0887