Neutron capture imaging of 10B in tissue specimens

Summary, in English

Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined.

• Författare: Crister Ceberg; Leif Salford; Arne Brun; Raphael J B Hemler; Bertil R Persson
• Avdelning/ar: Medicinsk strålningsfysik, Lund; Neurokirurgi; Tumörmikromiljö
• Publiceringsår: 1993
• Språk: Engelska
• Sidor: 139-146
• Publikation/Tidskrift/Serie: Radiotherapy and Oncology
• Volym: 26
• Issue: 2
• Länkar: http://dx.doi.org/10.1016/0167-8140(93)90095-P
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Radiology, Nuclear Medicine and Medical Imaging; Cancer and Oncology
• Nyckelord: BNCT; Glioma; Bio-distribution; Boron imaging; Track-films; Self-absorption
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1879-0887