Crister Ceberg
Professor
Neutron capture imaging of 10B in tissue specimens
Författare
Summary, in English
Boron Neutron Capture Therapy (BNCT) is an attractive concept for radiation treatment of malignant tumours. The patients receive a 10B-carrying compound with selective uptake in tumour cells, after which they are irradiated with epithermal neutrons. Theoretically, the tumour cells are killed by the high-LET particles produces in 10B(n, alpha)7Li reactions inside or close to the cell nucleus, while healthy brain cells with no boron uptake will be spared. In practice, a successful BNCT depends on the actual boron-distribution in the tissue, and consequently a new boron-compound aimed for BNCT must undergo detailed bio-distribution studies before clinical trials. In experimental work there is accordingly a great need for methods for quantitative bio-distribution measurements in tissue samples. In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. Particular attention has been paid to the correlation with the morphology of the specimens and to the altered self-absorption properties due to freeze-drying. A self-absorption correction factor for tumour tissue has been experimentally determined.
Avdelning/ar
- Medicinsk strålningsfysik, Lund
- Neurokirurgi
- Tumörmikromiljö
Publiceringsår
1993
Språk
Engelska
Sidor
139-146
Publikation/Tidskrift/Serie
Radiotherapy and Oncology
Volym
26
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Radiology, Nuclear Medicine and Medical Imaging
- Cancer and Oncology
Nyckelord
- BNCT
- Glioma
- Bio-distribution
- Boron imaging
- Track-films
- Self-absorption
Aktiv
Published
ISBN/ISSN/Övrigt
- ISSN: 1879-0887