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Ceberg

Crister Ceberg

Professor

Ceberg

Necrosis of malignant gliomas after intratumoral injection of 201Tl in vivo in the rat

Författare

  • H Sjöholm
  • Kaj Ljunggren
  • Reza Adeli
  • Arne Brun
  • Crister Ceberg
  • Sven-Erik Strand
  • Leif Salford

Summary, in English

Fourteen adult Fischer 344 rats were inoculated in vivo unilaterally in the caudate nucleus in the brain with malignant RG 2 glioma cells. By 3 weeks a tumor with a diameter of 3-6 mm normally develops. Ten animals which survived the repeated periods of anesthesia and thallium (Tl) injections (intratumorally three times of 201Tl, 15-23 days after inoculation) showed a prolonged retention of radioactivity at the site of injection with no uptake in other organs except for the kidneys. Singular circumscribed necroses were found post-mortem at the site of injection, comprising malignant glioma tumor tissue, which in six animals was absent, in three animals was markedly reduced in size compared with controls and in one animal had the expected size. In four animals metastases were found in distant locations in the brain; in three of these cases there was a retention of radioactivity in the tumor. The selective necrotizing effect on the tumor cells is interpreted as mainly due to emission of Auger electrons from intracellularly accumulated 201Tl, giving rise to very high energy deposition in the vicinity of the cell nucleus. The results should also have implications for the treatment of human malignant gliomas.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • Institutionen för kliniska vetenskaper, Malmö
  • Tumörmikromiljö
  • Neurokirurgi

Publiceringsår

1995

Språk

Engelska

Sidor

109-114

Publikation/Tidskrift/Serie

Anti-Cancer Drugs

Volym

6

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Rapid Communications

Ämne

  • Neurology
  • Cancer and Oncology
  • Clinical Medicine
  • Radiology, Nuclear Medicine and Medical Imaging
  • Surgery

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0959-4973