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Ceberg

Crister Ceberg

Professor

Ceberg

Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

Författare

  • Bertil R Persson
  • Catrin Baureus Koch
  • Gustav Grafström
  • Crister Ceberg
  • Per Munck af Rosenschöld
  • Bengt Widegren
  • Leif Salford

Summary, in English

Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.

Avdelning/ar

  • Rausinglaboratoriet i Lund - Tumörsektionen
  • Medicinsk strålningsfysik, Lund

Publiceringsår

2008

Språk

Engelska

Sidor

243-247

Publikation/Tidskrift/Serie

BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008

Volym

2

Dokumenttyp

Konferensbidrag

Förlag

IEEE - Institute of Electrical and Electronics Engineers Inc.

Ämne

  • Neurology
  • Surgery
  • Radiology, Nuclear Medicine and Medical Imaging

Conference name

1st International Conference on Biomedical Engineering and Informatics

Conference date

2008-05-27 - 2008-05-30

Conference place

Sanya, China

Status

Published

Forskningsgrupp

  • Rausing laboratory of Lund - Tumor section

ISBN/ISSN/Övrigt

  • ISBN: 9780769531182