Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Ceberg

Crister Ceberg

Professor

Ceberg

Development of dosimetric procedures for experimental ultra-high dose rate irradiation at a clinical linear accelerator

Författare

  • E. Konradsson
  • K. Petersson
  • G. Adrian
  • M. Lempart
  • B. Blad
  • S. Ceberg
  • T. Knöös
  • S. Å.J. Bäck
  • C. Ceberg

Summary, in English

As radiotherapy using ultra-high dose rates has gained new interest, the dosimetric challenges arising at these conditions needs to be addressed. Ionization chambers suffer from a large decrease in ion collection efficiency due to ion recombination, making on-line dosimetry difficult. In this work we present experimental setups and dosimetric procedures for FLASH irradiation of cells, zebrafish embryos and small animals using a 10 MeV electron beam at a modified clinical linear accelerator, and describe the dosimetric steps required to initiate clinical trials. The dosimetric equipment used for our pre-clinical experiments consisted of radiochromic film, thermoluminescent dosimeters, a Farmer-type ionization chamber and phantom material mimicking the experimental setup for irradiation. In preparation for small animal irradiation, dose profiles and depth dose curves were measured for all collimator sizes. The average dose rates were ≥620 Gy/s, ≥640 Gy/s and ≥400 Gy/s for cells, zebrafish embryos and small animals, respectively.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • Radiotherapy Physics
  • Strålterapi
  • LUCC: Lunds universitets cancercentrum
  • Medicinsk strålningsfysik, Malmö

Publiceringsår

2022-01

Språk

Engelska

Publikation/Tidskrift/Serie

Journal of Physics: Conference Series

Volym

2167

Dokumenttyp

Konferensbidrag

Förlag

IOP Publishing

Ämne

  • Cancer and Oncology
  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics

Conference name

11th International Conference on 3D Radiation Dosimetry, IC3DDose 2021

Conference date

2021-06-15

Conference place

Quebec City, Virtual, Canada

Status

Published

Forskningsgrupp

  • Radiotherapy Physics
  • Medical Radiation Physics, Malmö