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Ceberg

Crister Ceberg

Professor

Ceberg

Long-term anti-tumor effects following both conventional radiotherapy and FLASH in fully immunocompetent animals with glioblastoma

Författare

  • Emma Liljedahl
  • Elise Konradsson
  • Emma Gustafsson
  • Karolina Förnvik Jonsson
  • Jill K Olofsson
  • Crister Ceberg
  • Henrietta Nittby Redebrandt

Summary, in English

Radiotherapy can induce an immunological response. One limiting factor is side effects on normal tissue. Using FLASH radiotherapy, side effects could possibly be reduced. The efficacy of FLASH in relation to conventional radiotherapy (CONV-RT) has not been extensively explored in fully immunocompetent animals. Fully immunocompetent Fischer 344 rats were inoculated with NS1 glioblastoma cells subcutaneously or intracranially. Radiotherapy was delivered with FLASH or CONV-RT at 8 Gy × 2 (subcutaneous tumors) and 12.5 Gy × 2 (intracranial tumors). Cured animals were re-challenged in order to explore long-term anti-tumor immunity. Serum analytes and gene expression were explored. The majority of animals with subcutaneous tumors were cured when treated with FLASH or CONV-RT at 8 Gy × 2. Cured animals could reject tumor re-challenge. TIMP-1 in serum was reduced in animals treated with FLASH 8 Gy × 2 compared to control animals. Animals with intracranial tumors survived longer when treated with FLASH or CONV-RT at 12.5 Gy × 2, but cure was not reached. CONV-RT and FLASH were equally effective in fully immunocompetent animals with glioblastoma. Radiotherapy was highly efficient in the subcutaneous setting, leading to cure and long-term immunity in the majority of the animals.

Avdelning/ar

  • Neurokirurgi
  • Rausinglaboratoriet i Lund - Tumörsektionen
  • Radiotherapy Physics
  • Human neural utvecklingsbiologi

Publiceringsår

2022-07-19

Språk

Engelska

Sidor

12285-12285

Publikation/Tidskrift/Serie

Scientific Reports

Volym

12

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Cancer and Oncology
  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • Animals
  • Brain Neoplasms/etiology
  • Glioblastoma/etiology
  • Radiotherapy/adverse effects
  • Radiotherapy Dosage
  • Rats

Status

Published

Forskningsgrupp

  • Rausing laboratory of Lund - Tumor section
  • Radiotherapy Physics
  • Human Neural Developmental Biology

ISBN/ISSN/Övrigt

  • ISSN: 2045-2322