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Freddy Ståhlberg

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Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

Författare

  • Jacob W. Vogel
  • Yasser Iturria-Medina
  • Olof T. Strandberg
  • Ruben Smith
  • Elizabeth Levitis
  • Alan C. Evans
  • Oskar Hansson

Other contributions

  • Jimmy Lätt
  • Markus Nilsson
  • Freddy Ståhlberg
  • Pia Maly Sundgren
  • Danielle van Westen
  • Jonas Jögi
  • Douglas Hägerström
  • Tomas G Olsson
  • Per Wollmer

Summary, in English

Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these simulations to observed patterns measured using tau-PET in 312 individuals along Alzheimer's disease continuum. Up to 70% of the variance in the overall spatial pattern of tau can be explained by our model. Surprisingly, the ESM predicts the spatial patterns of tau irrespective of whether brain Aβ is present, but regions with greater Aβ burden show greater tau than predicted by connectivity patterns, suggesting a role of Aβ in accelerating tau spread. Altogether, our results provide evidence in humans that tau spreads through neuronal communication pathways even in normal aging, and that this process is accelerated by the presence of brain Aβ.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • Klinisk minnesforskning
  • MR Physics
  • Diagnostisk radiologi, Lund
  • eSSENCE: The e-Science Collaboration
  • Klinisk fysiologi, Lund
  • Klinisk neurofysiologi
  • Medicinsk strålningsfysik, Lund
  • Klinisk fysiologi och nuklearmedicin, Malmö

Publiceringsår

2020-05-26

Språk

Engelska

Publikation/Tidskrift/Serie

Nature Communications

Volym

11

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Neurosciences
  • Neurology

Status

Published

Forskningsgrupp

  • Clinical Memory Research
  • MR Physics
  • Clinical Physiology and Nuclear Medicine, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 2041-1723