Dynamic susceptibility contrast MRI with a prebolus contrast agent administration design for improved absolute quantification of perfusion.

Summary, in English

Arterial partial-volume effects (PVEs) often hamper reproducible absolute quantification of cerebral blood flow (CBF) and cerebral blood volume (CBV) obtained by dynamic susceptibility contrast MRI (DSC-MRI). The aim of this study was to examine whether arterial PVEs in DSC-MRI data can be minimized by rescaling the arterial input function (AIF) using a sagittal-sinus venous output function obtained following a prebolus administration of a low dose of contrast agent.

• Författare: Linda Knutsson; Emelie Lind; André Ahlgren; Matthias J P van Osch; Karin Markenroth Bloch; Yulia Surova; Freddy Ståhlberg; Danielle van Westen; Ronnie Wirestam
• Avdelning/ar: MultiPark: Multidisciplinary research focused on Parkinson´s disease; eSSENCE: The e-Science Collaboration; Medicinsk strålningsfysik, Lund; MR Physics; Klinisk fysiologi, Lund; Neurologi, Lund; Diagnostisk radiologi, Lund; Neuroradiologi
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 996-1006
• Publikation/Tidskrift/Serie: Magnetic Resonance in Medicine
• Volym: 72
• Issue: 4
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24285621?dopt=Abstract; http://dx.doi.org/10.1002/mrm.25006
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Radiology, Nuclear Medicine and Medical Imaging; Other Physics Topics
• Status: Published
• Projekt: Optimisation and Validation of Dynamic Susceptibility Contrast MRI
• Forskningsgrupp: MR Physics; Neuroradiology
• ISBN/ISSN/Övrigt: ISSN: 1522-2594