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Freddy Ståhlberg

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The importance of axonal undulation in diffusion MR measurements: a Monte Carlo simulation study.

Författare

  • Markus Nilsson
  • Jimmy Lätt
  • Freddy Ståhlberg
  • Danielle van Westen
  • Håkan Hagslätt

Summary, in English

Many axons follow wave-like undulating courses. This is a general feature of extracranial nerve segments, but is also found in some intracranial nervous tissue. The importance of axonal undulation has previously been considered, for example, in the context of biomechanics, where it has been shown that posture affects undulation properties. However, the importance of axonal undulation in the context of diffusion MR measurements has not been investigated. Using an analytical model and Monte Carlo simulations of water diffusion, this study compared undulating and straight axons in terms of diffusion propagators, diffusion-weighted signal intensities and parameters derived from diffusion tensor imaging, such as the mean diffusivity (MD), the eigenvalues and the fractional anisotropy (FA). All parameters were strongly affected by the presence of undulation. The diffusivity perpendicular to the undulating axons increased with the undulation amplitude, thus resembling that of straight axons with larger diameters. Consequently, models assuming straight axons for the estimation of the axon diameter from diffusion MR measurements might overestimate the diameter if undulation is present. FA decreased from approximately 0.7 to 0.5 when axonal undulation was introduced into the simulation model structure. Our results indicate that axonal undulation may play a role in diffusion measurements when investigating, for example, the optic and sciatic nerves and the spinal cord. The simulations also demonstrate that the stretching or compression of neuronal tissue comprising undulating axons alters the observed water diffusivity, suggesting that posture may be of importance for the outcome of diffusion MRI measurements. Copyright © 2011 John Wiley & Sons, Ltd.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • eSSENCE: The e-Science Collaboration
  • MR Physics
  • Medicinsk strålningsfysik, Lund
  • Diagnostisk radiologi, Lund
  • Neuroradiologi

Publiceringsår

2012

Språk

Engelska

Sidor

795-805

Publikation/Tidskrift/Serie

NMR in Biomedicine

Volym

25

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Forskningsgrupp

  • MR Physics
  • Neuroradiology

ISBN/ISSN/Övrigt

  • ISSN: 0952-3480