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Freddy Ståhlberg

Expert

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Gadolinium Contrast Agent is of Limited Value for Magnetic Resonance Imaging Assessment of Synovial Hypertrophy in Hemophiliacs.

Författare

  • Björn Lundin
  • Erik Berntorp
  • Holger Pettersson
  • Ronnie Wirestam
  • K Jonsson
  • Freddy Ståhlberg
  • Rolf Ljung

Summary, in English

Purpose: To examine the influence of different doses of gadolinium contrast agent on synovial enhancement, to compare magnetic resonance imaging (MRI) findings of synovial hypertrophy and radiographic joint changes in hemophiliacs, and to investigate the value of gadolinium in MRI assessment of synovial hypertrophy in hemophiliacs using dynamic MRI and MRI scoring. Material and Methods: Twenty-one hemophiliacs on prophylactic factor treatment without recent bleeds were subjected to radiography and gadolinium contrast-enhanced dynamic and static MRI of the knee using a standard dose of 0.1 mmol/kg b.w. gadoteridol. In 17 of the patients, the MRI procedure was repeated after a triple dose of gadoteridol. Results: MRI findings of synovial hypertrophy were significantly correlated with Pettersson radiographic scores. In 19 of the 21 MRI investigated joints, administration of contrast agent did not alter the result of the evaluation of synovial hypertrophy. Conclusion: The optimal time interval for volume assessment of synovial hypertrophy after injection of gadolinium contrast agent is dose dependent. Hemophiliacs without recent bleeds have minor to abundant synovial hypertrophy in joints with pronounced radiographic changes. Dynamic MRI is not useful for evaluating hemophilic arthropathy, and gadolinium contrast agent is not routinely indicated for MRI scoring of joints in hemophiliacs.

Avdelning/ar

  • Diagnostisk radiologi, Lund
  • Klinisk koagulationsmedicin, Malmö
  • Medicinsk strålningsfysik, Lund
  • Paediatric Hematologic Research Group
  • Pediatrisk hematologi

Publiceringsår

2007

Språk

Engelska

Sidor

520-530

Publikation/Tidskrift/Serie

Acta Radiologica

Volym

48

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

SAGE Publications

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Forskningsgrupp

  • Clinical Coagulation, Malmö
  • Paediatric Hematologic Research Group
  • Paediatric Haematology Research Unit

ISBN/ISSN/Övrigt

  • ISSN: 1600-0455