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Freddy Ståhlberg

Expert

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Circadian variation in human cerebrospinal fluid production measured by magnetic resonance imaging

Författare

  • C Nilsson
  • Freddy Ståhlberg
  • C Thomsen
  • O Henriksen
  • M Herning
  • Christer Owman

Summary, in English

Recent advances in magnetic resonance imaging have made it possible to visualize and quantify flow of cerebrospinal fluid (CSF) in the brain. The net flow of CSF through the cerebral aqueduct was used to measure CSF production in six normal volunteers at different times during a 24-h period. CSF production varied greatly both intra- and interindividually. The average CSF production in each time interval showed a clear tendency to circadian variation, with a minimum production 30% of maximum values (12 +/- 7 ml/h) approximately 1800 h and a nightly peak production approximately 0200 h of 42 +/- 2 ml/h. The total CSF production during the whole 24-h period, calculated as an average of all measurements, was 650 ml for the whole group and 630 ml for repeated measurements in each time interval in one of the volunteers.

Avdelning/ar

  • Diagnostisk radiologi, Lund
  • Drug Target Discovery

Publiceringsår

1992

Språk

Engelska

Sidor

20-24

Publikation/Tidskrift/Serie

American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

Volym

262

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

American Physiological Society

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging
  • Pharmacology and Toxicology

Status

Published

Forskningsgrupp

  • Drug Target Discovery

ISBN/ISSN/Övrigt

  • ISSN: 1522-1490