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Freddy Ståhlberg

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Partial volume correction of brain perfusion estimates using the inherent signal data of time-resolved arterial spin labeling.

Författare

  • André Ahlgren
  • Ronnie Wirestam
  • Esben Thade Petersen
  • Freddy Ståhlberg
  • Linda Knutsson

Summary, in English

Quantitative perfusion MRI based on arterial spin labeling (ASL) is hampered by partial volume effects (PVEs), arising due to voxel signal cross-contamination between different compartments. To address this issue, several partial volume correction (PVC) methods have been presented. Most previous methods rely on segmentation of a high-resolution T1 -weighted morphological image volume that is coregistered to the low-resolution ASL data, making the result sensitive to errors in the segmentation and coregistration. In this work, we present a methodology for partial volume estimation and correction, using only low-resolution ASL data acquired with the QUASAR sequence. The methodology consists of a T1 -based segmentation method, with no spatial priors, and a modified PVC method based on linear regression. The presented approach thus avoids prior assumptions about the spatial distribution of brain compartments, while also avoiding coregistration between different image volumes. Simulations based on a digital phantom as well as in vivo measurements in 10 volunteers were used to assess the performance of the proposed segmentation approach. The simulation results indicated that QUASAR data can be used for robust partial volume estimation, and this was confirmed by the in vivo experiments. The proposed PVC method yielded probable perfusion maps, comparable to a reference method based on segmentation of a high-resolution morphological scan. Corrected gray matter (GM) perfusion was 47% higher than uncorrected values, suggesting a significant amount of PVEs in the data. Whereas the reference method failed to completely eliminate the dependence of perfusion estimates on the volume fraction, the novel approach produced GM perfusion values independent of GM volume fraction. The intra-subject coefficient of variation of corrected perfusion values was lowest for the proposed PVC method. As shown in this work, low-resolution partial volume estimation in connection with ASL perfusion estimation is feasible, and provides a promising tool for decoupling perfusion and tissue volume. Copyright © 2014 John Wiley & Sons, Ltd.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • eSSENCE: The e-Science Collaboration
  • Medicinsk strålningsfysik, Lund
  • MR Physics

Publiceringsår

2014

Språk

Engelska

Sidor

1112-1122

Publikation/Tidskrift/Serie

NMR in Biomedicine

Volym

27

Issue

9

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Projekt

  • MRI brain perfusion quantification at 3 tesla using arterial spin labeling

Forskningsgrupp

  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 0952-3480