Cerebral perfusion information obtained by dynamic contrast-enhanced phase-shift magnetic resonance imaging: comparison with model-free arterial spin labelling.

Summary, in English

Summary Phase-shift time curves following a bolus injection of gadolinium contrast agent were registered for grey-matter regions and large vessels in 14 subjects. Deconvolving a tissue phase-shift curve with a phase-based arterial input function resulted in a tissue residue function R(t). The peak value of R(t) provided a relative cerebral blood flow (CBF) index, while the area-to-height ratio of R(t) provided quantitative mean transit time (MTT). For comparison, quantitative CBF values in grey matter were acquired using model-free arterial spin labelling (ASL). The phase-based relative CBF estimates showed good linear correlation with ASL-based CBF (r = 0.82). Grey-matter MTT was 4.9 +/- 1.1 s (mean +/- SD).

• Författare: Ronnie Wirestam; Emelie Lindgren; Danielle van Westen; Karin Markenroth Bloch; Freddy Ståhlberg; Linda Knutsson
• Avdelning/ar: MultiPark: Multidisciplinary research focused on Parkinson´s disease; eSSENCE: The e-Science Collaboration; Medicinsk strålningsfysik, Lund; MR Physics; Neuroradiologi; Diagnostisk radiologi, Lund
• Publiceringsår: 2010
• Språk: Engelska
• Sidor: 375-379
• Publikation/Tidskrift/Serie: Clinical Physiology and Functional Imaging
• Volym: 30
• Issue: 5
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/20618360?dopt=Abstract; http://dx.doi.org/10.1111/j.1475-097X.2010.00947.x
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Physiology; Other Physics Topics
• Status: Published
• Projekt: MRI brain perfusion quantification at 3 tesla using arterial spin labeling; Optimisation and Validation of Dynamic Susceptibility Contrast MRI
• Forskningsgrupp: MR Physics; Neuroradiology
• ISBN/ISSN/Övrigt: ISSN: 1475-0961