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Katarina Sjögreen Gleisner

Professor

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Biologically effective dose in fractionated molecular radiotherapy-application to treatment of neuroblastoma with (131)I-mIBG.

Författare

  • Pablo Minguez Gabina
  • Johan Ruben Gustafsson
  • Glenn Flux
  • Katarina Sjögreen Gleisner

Summary, in English

In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the time interval between administrations. The BED of tumour and liver is analysed in MRT of neuroblastoma with (131)I-mIBG, following a common two-administration protocol with a mass-based activity prescription. A BED analysis is also made for modified schedules, when due to local regulations there is a maximum permitted activity for each administration. Modifications include both the simplistic approach of delivering this maximum permitted activity in each of the two administrations, and also the introduction of additional administrations while maintaining the protocol-prescribed total activity. For the cases studied with additional (i.e. more than two) administrations, BED of tumour and liver decreases at most 12% and 29%, respectively. The decrease in BED of the tumour is however modest compared to the two-administration schedule using the maximum permitted activity, where the decrease compared to the original schedule is 47%.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2016

Språk

Engelska

Sidor

2532-2551

Publikation/Tidskrift/Serie

Physics in Medicine and Biology

Volym

61

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

IOP Publishing

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1361-6560