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Katarina Sjögreen Gleisner

Professor

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EANM practical guidance on uncertainty analysis for molecular radiotherapy absorbed dose calculations

Författare

  • Jonathan I. Gear
  • Maurice G. Cox
  • Johan Gustafsson
  • Katarina Sjögreen Gleisner
  • Iain Murray
  • Gerhard Glatting
  • Mark Konijnenberg
  • Glenn D. Flux

Summary, in English

A framework is proposed for modelling the uncertainty in the measurement processes constituting the dosimetry chain that are involved in internal absorbed dose calculations. The starting point is the basic model for absorbed dose in a site of interest as the product of the cumulated activity and a dose factor. In turn, the cumulated activity is given by the area under a time–activity curve derived from a time sequence of activity values. Each activity value is obtained in terms of a count rate, a calibration factor and a recovery coefficient (a correction for partial volume effects). The method to determine the recovery coefficient and the dose factor, both of which are dependent on the size of the volume of interest (VOI), are described. Consideration is given to propagating estimates of the quantities concerned and their associated uncertainties through the dosimetry chain to obtain an estimate of mean absorbed dose in the VOI and its associated uncertainty. This approach is demonstrated in a clinical example.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2018-12

Språk

Engelska

Sidor

2456-2474

Publikation/Tidskrift/Serie

European Journal of Nuclear Medicine and Molecular Imaging

Volym

45

Issue

13

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics

Nyckelord

  • Dosimetry
  • Uncertainty analysis

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1619-7070