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Linda Knutsson

Professor

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Brain Tumor Characterization Using Multibiometric Evaluation of MRI

Författare

  • Faris Durmo
  • Jimmy Lätt
  • Anna Rydelius
  • Silke Engelholm
  • Sara Kinhult
  • Krister Askaner
  • Elisabet Englund
  • Johan Bengzon
  • Markus Nilsson
  • Isabella M Björkman-Burtscher
  • Thomas Chenevert
  • Linda Knutsson
  • Pia C Sundgren
Visa allt

Summary, in English

The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG (n = 10), and MET (n = 15) were chosen. Preoperative magnetic resonance data included pre- and post-gadolinium contrast-enhanced T1-weighted fluid-attenuated inversion recover, cerebral blood flow (CBF), cerebral blood volume (CBV), fractional anisotropy, and apparent diffusion coefficient maps used for quantification of magnetic resonance biometrics by manual delineation of regions of interest. A binary logistic regression model was applied for multiparametric analysis and receiver operating characteristic (ROC) analysis. Statistically significant differences were found for normalized-ADC-tumor (nADC-T), normalized-CBF-tumor (nCBF-T), normalized-CBV-tumor (nCBV-T), and normalized-CBF-edema (nCBF-E) between LGG and HGG, and when these metrics were combined, HGG could be distinguished from LGG with a sensitivity and specificity of 100%. The only metric to distinguish HGG from MET was the normalized-ADC-E with a sensitivity of 68.8% and a specificity of 80%. LGG can be distinguished from MET by combining edema volume (Vol-E), Vol-E/tumor volume (Vol-T), nADC-T, nCBF-T, nCBV-T, and nADC-E with a sensitivity of 93.3% and a specificity of 100%. The present study confirms the usability of a multibiometric approach including volume, perfusion, and diffusion metrics in differentially diagnosing brain tumors in preoperative patients and adds to the growing body of evidence in the clinical field in need of validation and standardization.

Avdelning/ar

  • Diagnostisk radiologi, Lund
  • Neuroradiologi
  • Tumörmikromiljö
  • Diagnostisk radiologi, Malmö
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • Neurokirurgi
  • MR Physics
  • Multidimensional microstructure imaging
  • Lund University Bioimaging Center
  • Medicinsk strålningsfysik, Lund
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publiceringsår

2018-03

Språk

Engelska

Sidor

14-25

Publikation/Tidskrift/Serie

Tomography : a journal for imaging research

Volym

4

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Grapho Publications LLC

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics

Status

Published

Projekt

  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI

Forskningsgrupp

  • Neuroradiology
  • Radiology Diagnostics, Malmö
  • MR Physics
  • Multidimensional microstructure imaging

ISBN/ISSN/Övrigt

  • ISSN: 2379-1381