Absolute quantification of cerebral blood flow in neurologically normal volunteers: Dynamic-susceptibility contrast MRI-perfusion compared with computed tomography (CT)-perfusion

Summary, in English

To improve the reproducibility of arterial input function (AIF) registration and absolute cerebral blood flow (CBF) quantification in dynamic-susceptibility MRI-perfusion (MRP) at 1.5T, we rescaled the AIF by use of a venous output function (VOF). We compared CBF estimates of 20 healthy, elderly volunteers, obtained by computed tomography (CT)-perfusion (CTP) and MRP on two consecutive days. MRP, calculated without the AIF correction, did not result in any significant correlation with CTP. The rescaled MRP showed fair to moderate correlation with CTP for the central gray matter (GM) and the whole brain. Our results indicate that the method used for correction of partial volume effects (PVEs) improves MRP experiments by reducing AIF-introduced variance at 1.5T. Magn Reson Med, 2009.

• Författare: Ziegelitz Doerthe; Starck Göran; Mikkelsen Irene; Tullberg Mats; Edsbagge Mikael; Wikkelsö Carsten; Forsell-Aronsson Eva; Stig Holtås; Linda Knutsson
• Avdelning/ar: Diagnostisk radiologi, Lund; Medicinsk strålningsfysik, Lund; MR Physics
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 56-65
• Publikation/Tidskrift/Serie: Magnetic Resonance in Medicine
• Volym: 62
• Issue: 1
• Länkar: http://dx.doi.org/10.1002/mrm.21975
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Radiology, Nuclear Medicine and Medical Imaging
• Status: Published
• Projekt: Optimisation and Validation of Dynamic Susceptibility Contrast MRI
• Forskningsgrupp: MR Physics
• ISBN/ISSN/Övrigt: ISSN: 1522-2594