Linda Knutsson
Professor
Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach
Författare
Summary, in English
Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore the strategic location of WMH. The goal of this work was to develop a fully-automated method to identify predominant patterns of WMH across WM tracts based on cluster analysis. A total of 221 SLE patients with and without neuropsychiatric symptoms from two different sites were included in this study. WMH segmentations and lesion locations were acquired automatically. Cluster analysis was performed on the WMH distribution in 20 WM tracts. Our pipeline identified five distinct clusters with predominant involvement of the forceps major, forceps minor, as well as right and left anterior thalamic radiations and the right inferior fronto-occipital fasciculus. The patterns of the affected WM tracts were consistent over the SLE subtypes and sites. Our approach revealed distinct and robust tract-based WMH patterns within SLE patients. This method could provide a basis, to link the location of WMH with clinical symptoms. Furthermore, it could be used for other diseases characterized by presence of WMH to investigate both the clinical relevance of WMH and underlying pathomechanism in the brain.
Avdelning/ar
- MR Physics
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Klinisk minnesforskning
- Lund SLE Research Group
- EpiHealth: Epidemiology for Health
- eSSENCE: The e-Science Collaboration
- Neuroradiologi
- Multidimensional microstructure imaging
- Lund University Bioimaging Center
Publiceringsår
2022-12-09
Språk
Engelska
Sidor
1-12
Publikation/Tidskrift/Serie
Scientific Reports
Volym
12
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Other Physics Topics
- Radiology, Nuclear Medicine and Medical Imaging
Status
Published
Forskningsgrupp
- MR Physics
- Clinical Memory Research
- Lund SLE Research Group
- Neuroradiology
- Multidimensional microstructure imaging
ISBN/ISSN/Övrigt
- ISSN: 2045-2322