Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Default user image.

Linda Knutsson

Professor

Default user image.

Absolute quantification of cerebral blood flow: correlation between dynamic susceptibility contrast MRI and model-free arterial spin labeling.

Författare

  • Linda Knutsson
  • Danielle van Westen
  • Esben T Petersen
  • Karin Markenroth Bloch
  • Stig Holtås
  • Freddy Ståhlberg
  • Ronnie Wirestam

Summary, in English

PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous output function time integral obtained from the sagittal sinus. RESULTS: In GM, the average DSC-MRI CBF estimate was 150+/-45 ml/(min 100 g) (mean+/-SD) while the corresponding ASL CBF was 44+/-10 ml/(min 100 g). The linear correlation between GM CBF estimates obtained by DSC-MRI and ASL was r=.89, and observed DSC-to-ASL CBF ratios differed by less than 3% between GM and tumor regions. CONCLUSIONS: A satisfactory positive linear correlation between the CBF estimates obtained by model-free ASL and DSC-MRI was observed, and DSC-to-ASL CBF ratios showed no obvious tissue dependence.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • Medicinsk strålningsfysik, Lund
  • MR Physics
  • Neuroradiologi
  • Diagnostisk radiologi, Lund

Publiceringsår

2010

Språk

Engelska

Sidor

1-7

Publikation/Tidskrift/Serie

Magnetic Resonance Imaging

Volym

28

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Projekt

  • MRI brain perfusion quantification at 3 tesla using arterial spin labeling
  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI

Forskningsgrupp

  • MR Physics
  • Neuroradiology

ISBN/ISSN/Övrigt

  • ISSN: 1873-5894