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Linda Knutsson

Professor

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Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging

Författare

  • Hanna Jarnum
  • Elena G. Steffensen
  • Linda Knutsson
  • Ernst-Torben Frund
  • Carsten Wiberg Simonsen
  • Soren Lundbye-Christensen
  • Ajit Shankaranarayanan
  • David C. Alsop
  • Finn Taagehoj Jensen
  • Elna-Marie Larsson

Summary, in English

The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2010

Språk

Engelska

Sidor

307-317

Publikation/Tidskrift/Serie

Neuroradiology

Volym

52

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • Brain neoplasms
  • DSC-MRI
  • ASL
  • Magnetic resonance imaging
  • Perfusion

Status

Published

Projekt

  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI
  • MRI brain perfusion quantification at 3 tesla using arterial spin labeling

ISBN/ISSN/Övrigt

  • ISSN: 1432-1920