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Linda Knutsson

Professor

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Assessment of MRI contrast agent concentration by quantitative susceptibility mapping (QSM) : application to estimation of cerebral blood volume during steady state

Författare

  • Emelie Lind
  • Linda Knutsson
  • Robin Kämpe
  • Freddy Ståhlberg
  • Ronnie Wirestam

Summary, in English

Objective: One major issue in dynamic susceptibility contrast MRI (DSC-MRI) is to accurately determine contrast agent (CA) concentration, since T2* relaxivity in vivo is generally unknown and varies between blood and tissue. In this study, quantitative susceptibility mapping (QSM) was used for quantification of CA concentration. Materials and methods: A DSC-MRI protocol, including phase data acquisition, was applied to 20 healthy volunteers in a test–retest study. By selecting a CSF reference region of interest (ROI), the values of all QSM images were shifted to show no CA-induced change in CSF. CA concentration and cerebral blood volume (CBV) were estimated using shifted QSM data. CSF reference ROI optimization was evaluated by investigation of CBV repeatability. The CBV age dependence was analysed and tissue T2* relaxivity was estimated. Results: The best repeatability of CBV, using an optimal CSF reference ROI, showed test-versus-retest correlations of r = 0.81 and r = 0.91 for white and grey matter, respectively. A slight CBV decrease with age was observed, and the estimated in vivo T2* relaxivity was 85 mM−1s−1. Conclusion: Provided that a carefully selected CSF reference ROI is used to shift QSM image values, susceptibility information can be used to estimate concentration of contrast agent and to calculate CBV.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • Medicinsk strålningsfysik, Lund
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • MR Physics
  • Diagnostisk radiologi, Lund

Publiceringsår

2017-06-19

Språk

Engelska

Sidor

555-566

Publikation/Tidskrift/Serie

Magnetic Resonance Materials in Physics, Biology, and Medicine

Volym

30

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Other Clinical Medicine
  • Other Physics Topics

Nyckelord

  • Cerebral blood volume
  • Cerebrovascular circulation
  • Contrast agents
  • Magnetic resonance imaging
  • Magnetometry
  • QSM

Status

Published

Projekt

  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI

Forskningsgrupp

  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 0968-5243