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Linda Knutsson

Professor

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d-glucose weighted chemical exchange saturation transfer (glucoCEST)-based dynamic glucose enhanced (DGE) MRI at 3T : early experience in healthy volunteers and brain tumor patients

Författare

  • Xiang Xu
  • Akansha Ashvani Sehgal
  • Nirbhay N Yadav
  • John Laterra
  • Lindsay Blair
  • Jaishri Blakeley
  • Anina Seidemo
  • Jennifer M Coughlin
  • Martin G Pomper
  • Linda Knutsson
  • Peter C M van Zijl
Visa allt

Summary, in English

PURPOSE: Dynamic glucose enhanced (DGE) MRI has shown potential for imaging glucose delivery and blood-brain barrier permeability at fields of 7T and higher. Here, we evaluated issues involved with translating d-glucose weighted chemical exchange saturation transfer (glucoCEST) experiments to the clinical field strength of 3T.

METHODS: Exchange rates of the different hydroxyl proton pools and the field-dependent T2 relaxivity of water in d-glucose solution were used to simulate the water saturation spectra (Z-spectra) and DGE signal differences as a function of static field strength B0 , radiofrequency field strength B1 , and saturation time tsat . Multislice DGE experiments were performed at 3T on 5 healthy volunteers and 3 glioma patients.

RESULTS: Simulations showed that DGE signal decreases with B0 , because of decreased contributions of glucoCEST and transverse relaxivity, as well as coalescence of the hydroxyl and water proton signals in the Z-spectrum. At 3T, because of this coalescence and increased interference of direct water saturation and magnetization transfer contrast, the DGE effect can be assessed over a broad range of saturation frequencies. Multislice DGE experiments were performed in vivo using a B1 of 1.6 µT and a tsat of 1 second, leading to a small glucoCEST DGE effect at an offset frequency of 2 ppm from the water resonance. Motion correction was essential to detect DGE effects reliably.

CONCLUSION: Multislice glucoCEST-based DGE experiments can be performed at 3T with sufficient temporal resolution. However, the effects are small and prone to motion influence. Therefore, motion correction should be used when performing DGE experiments at clinical field strengths.

Avdelning/ar

  • MR Physics
  • Medicinsk strålningsfysik, Lund

Publiceringsår

2020-07

Språk

Engelska

Sidor

247-262

Publikation/Tidskrift/Serie

Magnetic Resonance in Medicine

Volym

84

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics

Status

Published

Projekt

  • Natural sugar as an MRI contrast agent for cancer diagnosis

Forskningsgrupp

  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 1522-2594