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Linda Knutsson

Professor

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Correlation between arterial blood volume obtained by arterial spin labelling and cerebral blood volume in intracranial tumours.

Författare

  • Danielle van Westen
  • Esben T Petersen
  • Ronnie Wirestam
  • Roger Siemund
  • Karin Markenroth Bloch
  • Freddy Ståhlberg
  • Isabella Björkman-Burtscher
  • Linda Knutsson

Summary, in English

OBJECTIVE: To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours. MATERIALS AND METHODS: Estimates of aBV from the model-free ASL technique quantitative STAR labelling of arterial regions (QUASAR) experiment and of DSC-CBV were obtained at 3T in ten patients with eleven tumours (three grade III gliomas, four glioblastomas and four meningiomas, two in one patient). Parametric values of aBV and CBV were determined in the tumour as well as in normal grey matter (GM), and tumour-to-GM aBV and CBV ratios were calculated. RESULTS: In a 4-pixel ROI representing maximal tumour values, the coefficient of determination R (2) was 0.61 for the comparison of ASL-based aBV tumour-to-GM ratios and DSC-MRI-based CBV tumour-to-GM ratios and 0.29 for the comparison of parametric values of ASL-aBV and DSC-CBV, under the assumption of proportionality. Both aBV and CBV showed a non-significant tendency to increase when going from grade III gliomas to glioblastomas to meningiomas. CONCLUSION: These results suggest that measurement of aBV is a potential tool for non-invasive assessment of blood volume in intracranial tumours.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • eSSENCE: The e-Science Collaboration
  • Neuroradiologi
  • Diagnostisk radiologi, Lund
  • Medicinsk strålningsfysik, Lund
  • MR Physics

Publiceringsår

2011

Språk

Engelska

Sidor

211-223

Publikation/Tidskrift/Serie

Magma

Volym

24

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Projekt

  • MRI brain perfusion quantification at 3 tesla using arterial spin labeling

Forskningsgrupp

  • Neuroradiology
  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 1352-8661