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X-ray Phase-contrast imaging

Martin Bech

Universitetslektor

X-ray Phase-contrast imaging

Microbubbles as a scattering contrast agent for grating-based x-ray dark-field imaging

Författare

  • A. Velroyen
  • Martin Bech
  • A. Malecki
  • A. Tapfer
  • A. Yaroshenko
  • M. Ingrisch
  • C. C. Cyran
  • S. D. Auweter
  • K. Nikolaou
  • M. Reiser
  • F. Pfeiffer
Visa allt

Summary, in English

In clinically established-absorption-based-biomedical x-ray imaging, contrast agents with high atomic numbers (e.g. iodine) are commonly used for contrast enhancement. The development of novel x-ray contrast modalities such as phase contrast and dark-field contrast opens up the possible use of alternative contrast media in x-ray imaging. We investigate using ultrasound contrast agents, which unlike iodine-based contrast agents can also be administered to patients with renal impairment and thyroid dysfunction, for application with a recently developed novel x-ray dark-field imaging modality. To produce contrast from these microbubble-based contrast agents, our method exploits ultra-small-angle coherent x-ray scattering. Such scattering dark-field x-ray images can be obtained with a grating-based x-ray imaging setup, together with refraction-based differential phase-contrast and the conventional attenuation contrast images. In this work we specifically show that ultrasound contrast agents based on microbubbles can be used to produce strongly enhanced dark-field contrast, with superior contrast-to-noise ratio compared to the attenuation signal. We also demonstrate that this method works well with an x-ray tube-based setup and that the relative contrast gain even increases when the pixel size is increased from tenths of microns to clinically compatible detector resolutions about up to a millimetre.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2013

Språk

Engelska

Sidor

37-46

Publikation/Tidskrift/Serie

Physics in Medicine and Biology

Volym

58

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

IOP Publishing

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1361-6560