Martin Bech
Universitetslektor
Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation
Författare
Summary, in English
Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.
Avdelning/ar
- Medicinsk strålningsfysik, Lund
Publiceringsår
2013
Språk
Engelska
Sidor
370-373
Publikation/Tidskrift/Serie
Proceedings - International Symposium on Biomedical Imaging
Dokumenttyp
Konferensbidrag
Ämne
- Radiology, Nuclear Medicine and Medical Imaging
Nyckelord
- dark-field
- emphysema
- grating interferometer
- phase-contrast
- x-ray
Conference name
2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
Conference date
2013-04-07 - 2013-04-11
Conference place
San Francisco, CA, United States
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1945-7928
- ISSN: 1945-8452
- ISBN: 978-1-4673-6455-3
- ISBN: 978-1-4673-6456-0