Grating-based X-ray Dark-field Computed Tomography of Living Mice.

Summary, in English

Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.

• Författare: A Velroyen; A Yaroshenko; D Hahn; A Fehringer; A Tapfer; M Müller; P B Noël; B Pauwels; A Sasov; A Ö Yildirim; O Eickelberg; K Hellbach; S D Auweter; F G Meinel; M F Reiser; Martin Bech; F Pfeiffer
• Avdelning/ar: Medicinsk strålningsfysik, Lund
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 1500-1506
• Publikation/Tidskrift/Serie: EBioMedicine
• Volym: 2
• Issue: 10
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26629545?dopt=Abstract; http://dx.doi.org/10.1016/j.ebiom.2015.08.014
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Radiology, Nuclear Medicine and Medical Imaging
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 2352-3964