Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

X-ray Phase-contrast imaging

Martin Bech

Universitetslektor

X-ray Phase-contrast imaging

Lung tumors on multimodal radiographs derived from grating-based X-ray imaging - A feasibility study

Författare

  • Felix G. Meinel
  • Felix Schwab
  • Andre Yaroshenko
  • Astrid Velroyen
  • Martin Bech
  • Katharina Hellbach
  • Jeanette Fuchs
  • Thorsten Stiewe
  • Ali Oe Yildirim
  • Fabian Bamberg
  • Maximilian F. Reiser
  • Franz Pfeiffer
  • Konstantin Nikolaou
Visa allt

Summary, in English

Purpose: The purpose of this study was to assess whether grating-based X-ray imaging may have a role in imaging of pulmonary nodules on radiographs. Materials and methods: A mouse lung containing multiple lung tumors was imaged using a small-animal scanner with a conventional X-ray source and a grating interferometer for phase-contrast imaging. We qualitatively compared the signal characteristics of lung nodules on transmission, dark-field and phase-contrast images. Furthermore, we quantitatively compared signal characteristics of lung tumors and the adjacent lung tissue and calculated the corresponding contrast-to-noise ratios. Results: Of the 5 tumors visualized on the transmission image, 3/5 tumors were clearly visualized and 1 tumor was faintly visualized in the dark-field image as areas of decreased small angle scattering. In the phase-contrast images, 3/5 tumors were clearly visualized, while the remaining 2 tumors were faintly visualized by the phase-shift occurring at their edges. No additional tumors were visualized in either the dark-field or phase-contrast images. Compared to the adjacent lung tissue, lung tumors were characterized by a significant decrease in transmission signal (median 0.86 vs. 0.91, p = 0.04) and increase in dark-field signal (median 0.71 vs. 0.65, p = 0.04). Median contrast-to-noise ratios for the visualization of lung nodules were 4.4 for transmission images and 1.7 for dark-field images (p = 0.04). Conclusion: Lung nodules can be visualized on all three radiograph modalities derived from grating-based X-ray imaging. However, our initial data suggest that grating-based multimodal X-ray imaging does not increase the sensitivity of chest radiographs for the detection of lung nodules. (C) 2013 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2014

Språk

Engelska

Sidor

352-357

Publikation/Tidskrift/Serie

Physica Medica

Volym

30

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • X-ray phase-contrast imaging
  • X-ray dark-field imaging
  • Chest
  • radiography
  • Lung tumors

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1120-1797