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Pharmacokinetic digital phantoms for accuracy assessment of image-based dosimetry in (177)Lu-DOTATATE peptide receptor radionuclide therapy.

Författare:
  • Gustav Brolin
  • Johan Ruben Gustafsson
  • Michael Ljungberg
  • Katarina Sjögreen Gleisner
Publiceringsår: 2015
Språk: Engelska
Sidor: 6131-6149
Publikation/Tidskrift/Serie: Physics in Medicine and Biology
Volym: 60
Nummer: 15
Dokumenttyp: Artikel i tidskrift
Förlag: IOP Publishing

Abstract english

Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms corresponding to patients treated with (177)Lu-DOTATATE. Three individual voxel phantoms from the XCAT population were generated and assigned a dynamic activity distribution based on a compartment model for (177)Lu-DOTATATE, designed specifically for this purpose. The compartment model was fitted to time-activity data from 10 patients, primarily acquired using quantitative scintillation camera imaging. S values for all phantom source-target combinations were calculated based on Monte-Carlo simulations. Combining the S values and time-activity curves, reference values of the absorbed dose to the phantom kidneys, liver, spleen, tumours and whole-body were calculated. The phantoms were used in a virtual dosimetry study, using Monte-Carlo simulated gamma-camera images and conventional methods for absorbed-dose calculations. The characteristics of the SPECT and WB planar images were found to well represent those of real patient images, capturing the difficulties present in image-based dosimetry. The phantoms are expected to be useful for further studies and optimisation of clinical dosimetry in (177)Lu PRRT.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging

Other

Published
  • ISSN: 1361-6560
Michael Ljungberg
E-post: michael [dot] ljungberg [at] med [dot] lu [dot] se

Professor

Medicinsk strålningsfysik, Lund

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Avdelningschef

Medicinsk strålningsfysik, Lund

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Avdelningsföreståndare

Medicinsk strålningsfysik, Lund

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Projektledare

Nuclear Medicine Physics

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