
Michael Ljungberg
Professor

Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy
Författare
Summary, in English
Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions.
Avdelning/ar
- Medicinsk strålningsfysik, Lund
Publiceringsår
2015
Språk
Engelska
Sidor
296-317
Publikation/Tidskrift/Serie
Diagnostics
Volym
5
Issue
3
Fulltext
Dokumenttyp
Artikel i tidskrift
Förlag
MDPI AG
Ämne
- Radiology, Nuclear Medicine and Medical Imaging
Nyckelord
- dosimetry
- Monte Carlo
- SPECT
- hybrid
- CT
- absorbed dose
- therapy
- reconstruction
- quantitation
- activity
Aktiv
Published
ISBN/ISSN/Övrigt
- ISSN: 2075-4418