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Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy

Författare:
  • Michael Ljungberg
  • Katarina Sjögreen Gleisner
Publiceringsår: 2015
Språk: Engelska
Sidor: 296-317
Publikation/Tidskrift/Serie: Diagnostics
Volym: 5
Nummer: 3
Dokumenttyp: Artikel i tidskrift
Förlag: MDPI AG

Abstract english

Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging
  • dosimetry
  • Monte Carlo
  • SPECT
  • hybrid
  • CT
  • absorbed dose
  • therapy
  • reconstruction
  • quantitation
  • activity

Other

Published
  • ISSN: 2075-4418
Michael Ljungberg
E-post: michael [dot] ljungberg [at] med [dot] lu [dot] se

Professor

Medicinsk strålningsfysik, Lund

+46 46 17 35 65

+46 70 817 31 15

SUS Lund Kampradhuset 12-11

Barngatan 2:1, Lund

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Avdelningschef

Medicinsk strålningsfysik, Lund

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Avdelningsföreståndare

Medicinsk strålningsfysik, Lund

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Projektledare

Nuclear Medicine Physics

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