Meny

Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy.

Författare:
  • David Minarik
  • Katarina Sjögreen Gleisner
  • Ola Lindén
  • Karin Wingårdh
  • Jan Tennvall
  • Sven-Erik Strand
  • Michael Ljungberg
Publiceringsår: 2010
Språk: Engelska
Sidor: 1974-1978
Publikation/Tidskrift/Serie: Journal of Nuclear Medicine
Volym: 51
Nummer: 12
Dokumenttyp: Artikel i tidskrift
Förlag: Society of Nuclear Medicine

Abstract english

This feasibility study demonstrates (90)Y quantitative bremsstrahlung imaging of patients undergoing high-dose myeloablative (90)Y-ibritumomab treatment. METHODS: The study includes pretherapy (111)In SPECT/CT and planar whole-body (WB) imaging at 7 d and therapy (90)Y SPECT/CT at 6 d and (90)Y WB imaging at 1 d. Time-activity curves and organ-absorbed doses derived from (90)Y SPECT images were compared with pretherapy (111)In estimates. Organ activities derived from (90)Y WB images at the first day were compared with corresponding pretherapy estimates. RESULTS: Pretherapy (111)In images from 3 patients were similar to the (90)Y images. Differences between absorbed-dose estimates from pretherapy (111)In and (90)Y therapy were within 25%, except for the lungs. Corresponding activity differences derived from WB images were within 25%. Differences were ascribed to incomplete compensation methods and real differences in pharmacokinetics between pretherapy and therapy. CONCLUSION: Quantitative bremsstrahlung imaging to estimate organ activities and absorbed doses is feasible.

Keywords

  • Radiology, Nuclear Medicine and Medical Imaging
  • quantification
  • activity
  • radioimmunotherapy
  • imaging
  • yttrium
  • bremsstrahlung

Other

Published
  • ISSN: 0161-5505
Michael Ljungberg
E-post: michael [dot] ljungberg [at] med [dot] lu [dot] se

Professor

Medicinsk strålningsfysik, Lund

+46 46 17 35 65

+46 70 817 31 15

SUS Lund Kampradhuset 12-11

Barngatan 2:1, Lund

32

Avdelningschef

Medicinsk strålningsfysik, Lund

32

Avdelningsföreståndare

Medicinsk strålningsfysik, Lund

32

Projektledare

Nuclear Medicine Physics

32