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Michael Ljungberg

Michael Ljungberg

Professor

Michael Ljungberg

Dynamic (99m)Tc-MAG3 renography: images for quality control obtained by combining pharmacokinetic modelling, an anthropomorphic computer phantom and Monte Carlo simulated scintillation camera imaging.

Författare

  • Gustav Brolin
  • Katarina Sjögreen Gleisner
  • Michael Ljungberg

Summary, in English

In dynamic renal scintigraphy, the main interest is the radiopharmaceutical redistribution as a function of time. Quality control (QC) of renal procedures often relies on phantom experiments to compare image-based results with the measurement setup. A phantom with a realistic anatomy and time-varying activity distribution is therefore desirable. This work describes a pharmacokinetic (PK) compartment model for (99m)Tc-MAG3, used for defining a dynamic whole-body activity distribution within a digital phantom (XCAT) for accurate Monte Carlo (MC)-based images for QC. Each phantom structure is assigned a time-activity curve provided by the PK model, employing parameter values consistent with MAG3 pharmacokinetics. This approach ensures that the total amount of tracer in the phantom is preserved between time points, and it allows for modifications of the pharmacokinetics in a controlled fashion. By adjusting parameter values in the PK model, different clinically realistic scenarios can be mimicked, regarding, e.g., the relative renal uptake and renal transit time. Using the MC code SIMIND, a complete set of renography images including effects of photon attenuation, scattering, limited spatial resolution and noise, are simulated. The obtained image data can be used to evaluate quantitative techniques and computer software in clinical renography.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2013

Språk

Engelska

Sidor

3145-3161

Publikation/Tidskrift/Serie

Physics in Medicine and Biology

Volym

58

Issue

10

Dokumenttyp

Artikel i tidskrift

Förlag

IOP Publishing

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1361-6560