Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Michael Ljungberg

Michael Ljungberg

Professor

Michael Ljungberg

A validation protocol for 177Lu-SPECT image quantification as a basis for multi-centre kidney dosimetry

Författare

  • Lovisa Jessen
  • Selma Curkic Kapidzic
  • Johan Gustafsson
  • Erik Larsson
  • Michael Ljungberg
  • Mattias Sandström
  • Johanna Dalmo
  • Linn Hagmarker
  • Cecilia Hindorf
  • Jan Taprogge
  • Jonathan Gear
  • Glenn Flux
  • Katarina Sjögreen Gleisner
Visa allt

Summary, in English

Objective. Multicentre studies in molecular radiotherapy face challenges in ensuring the comparability of dosimetry results. The aim of this study was to develop a validation protocol to achieve equivalent 177Lu-SPECT quantification across centres, consisting of a test exercise in combination with an action level. Approach. 177Lu-SPECT/CT imaging of 3D-printed kidney phantoms with non-uniform activity distributions was conducted at five hospitals in Sweden and the UK. In total, 12 quantification systems (QSs) were included, where a QS was defined as the combination of a given camera system, reconstruction method and image-analysis method. The accuracy of image-based estimates of the activity concentration was investigated for three approaches to multicentre dosimetry: one site-specific, and two variants of centralised approaches. For the site-specific approach, the reference value was blinded to the evaluating operators. Prior to the evaluation, the participants agreed on an action level, specified as an obtained deviation larger than ±10% from the reference value. Sites responsible for a QS that yielded larger deviations, and therefore did not comply, were required to present an action plan, i.e., a plan for further method optimisation. Main results. For the site-specific approach, deviations larger than 10% were obtained for six out of 12 QS (range −11% to +27%). Action plans were presented for these QS and was implemented by one site (two QS). For the two variants of centralised approaches, where nine QS were included in total, deviations of within 10% were obtained for nine and seven QS, respectively. Significance. A quantification test combined with an action level can serve as an initial validation to enable further development and to achieve equivalent 177Lu-SPECT quantification across sites.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • Nuclear Medicine Physics
  • LUCC: Lunds universitets cancercentrum

Publiceringsår

2025-06

Språk

Engelska

Publikation/Tidskrift/Serie

Physics in Medicine and Biology

Volym

70

Avvikelse

11

Dokumenttyp

Artikel i tidskrift

Förlag

IOP Publishing

Ämne

  • Radiology and Medical Imaging

Nyckelord

  • comparability
  • equivalent dosimetry
  • multicentre clinical trials
  • quantitative Lu-SPECT

Aktiv

Published

Forskningsgrupp

  • Nuclear Medicine Physics

ISBN/ISSN/Övrigt

  • ISSN: 0031-9155