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Selection of collimator for rCBF studies and evaluation of triple-headed SPET using noise-resolution plots

  • A Ärlig
  • L Jacobsson
  • A Larsson
  • Michael Ljungberg
  • C Wikkelso
Publiceringsår: 1997
Språk: Engelska
Sidor: 655-661
Publikation/Tidskrift/Serie: Nuclear Medicine Communications
Volym: 18
Nummer: 7
Dokumenttyp: Artikel i tidskrift
Förlag: Lippincott Williams & Wilkins

Abstract english

We investigated the effect of collimator selection on image quality in regional cerebral blood flow (rCBF) studies of the brain performed with 99Tc(m)-HMPAO. A triple-headed SPET system (GE/CGR Neurocam) was used, together with three sets of parallel-hole collimators - general-purpose (GP), high-resolution (HR) and ultra-high-resolution (UHR). Two image quality parameters were used to describe the image quality, namely, noise and resolution. Noise was measured in experimental and Monte-Carlo simulated SPET studies of a cylinder phantom of uniform activity as the pixel root mean square error (RMS) and as the coefficient of variation (CV) of quantitative rCBF values. Resolution was measured as full-width at half-maximum in experimental SPET studies of a line-source. Plots of noise versus resolution for the different collimators were obtained by varying the cut-off frequency of the Hanning filter applied in the reconstruction of transaxial slices. From these noise-resolution plots, we were able to determine which collimator gave the best resolution for a specific noise level. A lowest reasonable noise level may be established by comparison with the inter-observer CV of the quantification method.


  • Radiology, Nuclear Medicine and Medical Imaging


  • ISSN: 1473-5628
Michael Ljungberg
E-post: michael [dot] ljungberg [at] med [dot] lu [dot] se


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Medicinsk strålningsfysik, Lund



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Nuclear Medicine Physics