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Michael Ljungberg

Michael Ljungberg

Professor

Michael Ljungberg

3D absorbed dose calculations based on SPECT: Evaluation for 111-In/90-Y therapy using Monte Carlo simulations.

Författare

  • Michael Ljungberg
  • E Frey
  • Katarina Sjögreen Gleisner
  • XW Liu
  • Y Dewaraja
  • Sven-Erik Strand

Summary, in English

A general method is presented for patient-specific three-dimensional (3D) absorbed dose calculations based on quantitative SPECT activity measurements. The computational scheme includes a method for registration of the CT study to the SPECT image, and compensation for attenuation, scatter, and collimator-detector response including septal penetration, performed as part of an iterative reconstruction method. From SPECT images, the absorbed dose rate is calculated using an EGS4 Monte Carlo code, which converts the activity distribution to an absorbed dose rate distribution. Evaluation of the accuracy in the activity quantification and the absorbed dose calculation is based on realistic Monte Carlo simulated SPECT data of a voxel-computer phantom and In-111 and Y-90. Septal penetration was not included in this study. The SPECT-based activity concentrations and absorbed dose distributions are compared to the actual values; the results imply that the corrections for attenuation and scatter yield results of high accuracy. The presented method includes compensation for most parameters deteriorating the quantitative image information. Inaccuracies are, however, introduced by the limited spatial resolution of the SPECT system, which are not fully compensated by the collimator-response correction. The proposed evaluation methodology may be used as a basis for future inter-comparison of different dosimetry calculation schemes.

Avdelning/ar

  • Sektion V

Publiceringsår

2003

Språk

Engelska

Sidor

99-107

Publikation/Tidskrift/Serie

Cancer Biotherapy & Radiopharmaceuticals

Volym

18

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Mary Ann Liebert, Inc.

Ämne

  • Cancer and Oncology

Nyckelord

  • simulation
  • attenuation
  • scatter
  • quantification
  • SPECT
  • Monte Carlo
  • dosimetry

Aktiv

Published

ISBN/ISSN/Övrigt

  • ISSN: 1557-8852