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3-D Monte Carlo-based scatter compensation in quantitative I-131SPECT reconstruction

  • YK Dewaraja
  • Michael Ljungberg
  • JA Fessler
Publiceringsår: 2006
Språk: Engelska
Sidor: 181-188
Publikation/Tidskrift/Serie: IEEE Transactions on Nuclear Science
Volym: 53
Nummer: 1
Dokumenttyp: Artikel i tidskrift
Förlag: IEEE--Institute of Electrical and Electronics Engineers Inc.

Abstract english

We have implemented highly accurate Monte Carlo based scatter modeling (MCS) with 3-D ordered subsets expectation maximization (OSEM) reconstruction for I-131 single photon emission computed tomography (SPECT). The scatter is included in the statistical model as an additive term and attenuation and detector response are included in the forward/backprojector. In the present implementation of MCS, a simple multiple window-based estimate is used for the initial iterations and in the later iterations the Monte Carlo estimate is used for several iterations before it is updated. For I-131, MCS was evaluated and compared with triple energy window (TEW) scatter compensation using simulation studies of a mathematical phantom and a clinically realistic voxel-phantom. Even after just two Monte Carlo updates, excellent agreement was found between the MCS estimate and the true scatter distribution. Accuracy and noise of the reconstructed images were superior with MCS compared to TEW. However, the improvement was not large, and in some cases may not justify the large computational requirements of MCS. Furthermore, it was shown that the TEW correction could be improved for most of the targets investigated here by applying a suitably chosen scaling factor to the scatter estimate. Finally clinical application of MCS was demonstrated by applying the method to an I-131 radioimmunotherapy (RIT) patient study.


  • Radiology, Nuclear Medicine and Medical Imaging
  • SPECT quantification
  • scatter correction
  • Monte Carlo
  • I-131SPECT
  • image reconstruction


  • ISSN: 0018-9499
Michael Ljungberg
E-post: michael [dot] ljungberg [at] med [dot] lu [dot] se


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Medicinsk strålningsfysik, Lund



Medicinsk strålningsfysik, Lund



Nuclear Medicine Physics