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Michael Ljungberg

Michael Ljungberg

Professor

Michael Ljungberg

3-D Monte Carlo-based scatter compensation in quantitative I-131SPECT reconstruction

Författare

  • YK Dewaraja
  • Michael Ljungberg
  • JA Fessler

Summary, in English

We have implemented highly accurate Monte Carlo based scatter modeling (MCS) with 3-D ordered subsets expectation maximization (OSEM) reconstruction for I-131 single photon emission computed tomography (SPECT). The scatter is included in the statistical model as an additive term and attenuation and detector response are included in the forward/backprojector. In the present implementation of MCS, a simple multiple window-based estimate is used for the initial iterations and in the later iterations the Monte Carlo estimate is used for several iterations before it is updated. For I-131, MCS was evaluated and compared with triple energy window (TEW) scatter compensation using simulation studies of a mathematical phantom and a clinically realistic voxel-phantom. Even after just two Monte Carlo updates, excellent agreement was found between the MCS estimate and the true scatter distribution. Accuracy and noise of the reconstructed images were superior with MCS compared to TEW. However, the improvement was not large, and in some cases may not justify the large computational requirements of MCS. Furthermore, it was shown that the TEW correction could be improved for most of the targets investigated here by applying a suitably chosen scaling factor to the scatter estimate. Finally clinical application of MCS was demonstrated by applying the method to an I-131 radioimmunotherapy (RIT) patient study.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2006

Språk

Engelska

Sidor

181-188

Publikation/Tidskrift/Serie

IEEE Transactions on Nuclear Science

Volym

53

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

IEEE - Institute of Electrical and Electronics Engineers Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • SPECT quantification
  • scatter correction
  • Monte Carlo
  • I-131SPECT
  • image reconstruction

Aktiv

Published

ISBN/ISSN/Övrigt

  • ISSN: 0018-9499