Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Default user image.

Ronnie Wirestam

Professor

Default user image.

Dynamic susceptibility contrast perfusion MRI using phase-based venous output functions: : comparison with pseudo-continuous arterial spin labelling and assessment of contrast agent concentration in large veins.

Författare

  • Ronnie Wirestam
  • Emelie Lind
  • André Ahlgren
  • Freddy Ståhlberg
  • Linda Knutsson

Summary, in English

OBJECTIVES: Contrast agent (CA) relaxivities are generally not well established in vivo, and the relationship between frequency/phase shift and magnetic susceptibility might be a useful alternative for CA quantification.

MATERIALS AND METHODS: Twenty volunteers (25-84 years old) were investigated using test-retest pre-bolus dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI). The pre-bolus phase-based venous output function (VOF) time integral was used for arterial input function (AIF) rescaling. Resulting cerebral blood flow (CBF) data for grey matter (GM) were compared with pseudo-continuous arterial spin labelling (ASL). During the main bolus CA passage, the apparent spatial shift (pixel shift) of the superior sagittal sinus (seen in single-shot echo-planar imaging (EPI)) was converted to CA concentration and compared with conventional ΔR2*-based data and with a predicted phase-based VOF from the pre-bolus experiment.

RESULTS: The phase-based pre-bolus VOF resulted in a reasonable inter-individual GM CBF variability (coefficient of variation 28 %). Comparison with ASL CBF values implied a tissue R2*-relaxivity of 32 mM(-1) s(-1). Pixel-shift data at low concentrations (data not available at peak concentrations) were in reasonable agreement with the predicted phase-based VOF.

CONCLUSION: Susceptibility-induced phase shifts and pixel shifts are potentially useful for large-vein CA quantification. Previous predictions of a higher R2*-relaxivity in tissue than in blood were supported.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Diagnostisk radiologi, Lund
  • MR Physics
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publiceringsår

2016-12

Språk

Engelska

Sidor

823-831

Publikation/Tidskrift/Serie

Magnetic Resonance Materials in Physics, Biology, and Medicine

Volym

29

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Medical Image Processing
  • Other Physics Topics

Aktiv

Published

Projekt

  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI
  • MRI brain perfusion quantification at 3 tesla using arterial spin labeling

Forskningsgrupp

  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 1352-8661