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Ronnie Wirestam

Professor

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Dynamic susceptibility contrast perfusion MRI using phase-based venous output functions: : comparison with pseudo-continuous arterial spin labelling and assessment of contrast agent concentration in large veins.

Författare

  • Ronnie Wirestam
  • Emelie Lind
  • André Ahlgren
  • Freddy Ståhlberg
  • Linda Knutsson

Summary, in English

OBJECTIVES: Contrast agent (CA) relaxivities are generally not well established in vivo, and the relationship between frequency/phase shift and magnetic susceptibility might be a useful alternative for CA quantification.

MATERIALS AND METHODS: Twenty volunteers (25-84 years old) were investigated using test-retest pre-bolus dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI). The pre-bolus phase-based venous output function (VOF) time integral was used for arterial input function (AIF) rescaling. Resulting cerebral blood flow (CBF) data for grey matter (GM) were compared with pseudo-continuous arterial spin labelling (ASL). During the main bolus CA passage, the apparent spatial shift (pixel shift) of the superior sagittal sinus (seen in single-shot echo-planar imaging (EPI)) was converted to CA concentration and compared with conventional ΔR2*-based data and with a predicted phase-based VOF from the pre-bolus experiment.

RESULTS: The phase-based pre-bolus VOF resulted in a reasonable inter-individual GM CBF variability (coefficient of variation 28 %). Comparison with ASL CBF values implied a tissue R2*-relaxivity of 32 mM(-1) s(-1). Pixel-shift data at low concentrations (data not available at peak concentrations) were in reasonable agreement with the predicted phase-based VOF.

CONCLUSION: Susceptibility-induced phase shifts and pixel shifts are potentially useful for large-vein CA quantification. Previous predictions of a higher R2*-relaxivity in tissue than in blood were supported.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Diagnostisk radiologi, Lund
  • MR Physics
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publiceringsår

2016-12

Språk

Engelska

Sidor

823-831

Publikation/Tidskrift/Serie

Magnetic Resonance Materials in Physics, Biology, and Medicine

Volym

29

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Medical Imaging
  • Other Physics Topics

Aktiv

Published

Projekt

  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI
  • MRI brain perfusion quantification at 3 tesla using arterial spin labeling

Forskningsgrupp

  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 1352-8661