Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Default user image.

Ronnie Wirestam

Professor

Default user image.

Absolute cerebral blood flow measured by dynamic susceptibility contrast MRI: a direct comparison with Xe-133 SPECT

Författare

  • Ronnie Wirestam
  • Erik Ryding
  • Arne Lindgren
  • Bo Geijer
  • Stig Holtås
  • Freddy Ståhlberg

Summary, in English

Absolute regional cerebral blood flow (CBF) was measured in ten healthy volunteers, using both dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI) and Xe-133 SPECT within 4 h. After i.v. injection of Gd-DTPA-BMA (0.3 mmol/kg b.w.), the bolus was monitored with a Simultaneous Dual FLASH pulse sequence (1.5 s/image), providing one slice through brain tissue and a second slice through the carotid artery. Concentration C(t) is proportional to -(1/TE) ln[S(t)/S(0)] was related to CBF as C(t) = CBF [AIF(t) x R(t)], where AIF is the arterial input function and R(t) is the residue function. A singular-value-decomposition-based deconvolution technique was used for retrieval of R(t). Absolute CBF was given by Zierler's area-to-height relation and the central volume principle. For elimination of large vessels (ELV), all MRI-based CBF values exceeding 2.5 times the mean CBF value of the slice were excluded. A correction for partial-volume effects (CPVE) in the artery used for AIF monitoring was based on registration of signal in a phantom with tubes of various diameters (1.5-6.5 mm), providing an individual concentration correction factor applied to AIF data registered in vivo. In the Xe-133 SPECT investigation, 3,000-4,000 MBq of Xe-133 was administered intravenously, and CBF was calculated using the Kanno Lassen algorithm. When ELV and CPVE were applied, DSC-MRI showed average CBF values from the entire slice of 43 +/- 10 ml/(min 100 g) (small-artery AIF) and 48 +/- 17 ml/(min 100 g) (carotid-artery AIF) (mean +/- S.D., n = 10). The corresponding Xe-133-SPECT-based CBF was 33 +/- 6 ml/(min 100 g) (n = 10). The relationships of CBF(MRI) versus CBF(SPECT) showed good linear correlation (r = 0.74-0.83).

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • Klinisk neurofysiologi
  • Neurologi, Lund
  • Diagnostisk radiologi, Lund

Publiceringsår

2000

Språk

Engelska

Sidor

96-103

Publikation/Tidskrift/Serie

Magma

Volym

11

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • Cerebral blood flow
  • Perfusion
  • Magnetic resonance imaging
  • Bolus tracking
  • Xc-133 SPECT
  • Normal subjects

Aktiv

Published

Projekt

  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI

ISBN/ISSN/Övrigt

  • ISSN: 1352-8661