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Ronnie Wirestam

Professor

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Assessment of regional cerebral blood flow by dynamic susceptibility contrast MRI using different deconvolution techniques

Författare

  • Ronnie Wirestam
  • Linda Knutsson
  • Leif Ostergaard
  • Max Bolling
  • Juha-Petri Aunola
  • Arne Lindgren
  • Bo Geijer
  • Stig Holtås
  • Freddy Ståhlberg

Summary, in English

Regional cerebral blood flow (rCBF) was assessed using dynamic susceptibility-contrast MRI at 1.5 T. A simultaneous dual FLASH pulse sequence and Gd-DTPA-BMA (0.3 mmol/kg b.w.) were used for examination of 43 volunteers, measuring rCBF in frontal white matter (WM) and in gray matter in the thalamus (GM). Arterial input functions (AIFs) were registered 1) in the carotid artery and 2) in an artery within the GM/WM slice. The measured concentration-vs. -time curve was deconvolved with the AIF using both Fourier Transform (FT) and Singular Value Decomposition (SVD). Relative rCBF was given by the height of the deconvolved response curve. For each volunteer, eight different rCBF maps were calculated, representing different combinations of deconvolution techniques, AIFs, and filters. The average GM-WM rCBF ratios ranged from 2.0-2.2, depending on methodology. Absolute rCBF was 68 +/- 28 ml/(min 100 g) in GM and 35 +/- 13 ml/(min 100g) in WM (mean +/- SD, n = 39). GM-WM rCBF ratios obtained using SVD were 6-10% higher than corresponding ratios obtained using FT.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • MR Physics
  • Neurologi, Lund
  • Diagnostisk radiologi, Lund

Publiceringsår

2000

Språk

Engelska

Sidor

691-700

Publikation/Tidskrift/Serie

Magnetic Resonance in Medicine

Volym

43

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • cerebral blood flow (CBF)
  • dynamic susceptibility-contrast magnetic resonance imaging (MRI)
  • nonparametric deconvolution
  • arterial input function

Status

Published

Projekt

  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI

Forskningsgrupp

  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 1522-2594