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Ronnie Wirestam

Professor

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Can resting-state functional MRI serve as a complement to task-based mapping of sensorimotor function? A test-retest reliability study in healthy volunteers.

Författare

  • Peter Mannfolk
  • Markus Nilsson
  • Henrik Hansson
  • Freddy Ståhlberg
  • Peter Fransson
  • Andreas Weibull
  • Jonas Svensson
  • Ronnie Wirestam
  • Johan Olsrud

Summary, in English

PURPOSE: To investigate if resting-state functional MRI (fMRI) reliably can serve as a complement to task-based fMRI for presurgical mapping of the sensorimotor cortex. MATERIALS AND METHODS: Functional data were obtained in 10 healthy volunteers using a 3 Tesla MRI system. Each subject performed five bilateral finger tapping experiments interleaved with five resting-state experiments. Following preprocessing, data from eight volunteers were further analyzed with the general linear model (finger tapping data) and independent component analysis (rest data). Test-retest reliability estimates (hit rate and false alarm rate) for resting-state fMRI activation of the sensorimotor network were compared with the reliability estimates for task-evoked activation of the sensorimotor cortex. The reliability estimates constituted a receiver operating characteristics curve from which the area under the curve (AUC) was calculated. Statistical testing was performed to compare the two groups with respect to reliability. RESULTS: The AUC was generally higher for the task experiments, although median AUC was not significantly different on a group level. Also, the two groups showed comparable levels of within-group variance. CONCLUSION: Test-retest reliability was comparable between resting-state measurements and task-based fMRI, suggesting that presurgical mapping of functional networks can be a supplement to task-based fMRI in cases where patient status excludes task-based fMRI. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • eSSENCE: The e-Science Collaboration
  • Medicinsk strålningsfysik, Lund
  • MR Physics
  • Diagnostisk radiologi, Lund
  • Medicinsk strålningsfysik, Malmö

Publiceringsår

2011

Språk

Engelska

Sidor

511-517

Publikation/Tidskrift/Serie

Journal of Magnetic Resonance Imaging

Volym

34

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Aktiv

Published

Forskningsgrupp

  • MR Physics
  • Medical Radiation Physics, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1522-2586