Regional cerebral blood flow distributions in normal volunteers: dynamic susceptibility contrast MRI compared with 99mTc-HMPAO SPECT

Summary, in English

PURPOSE: Relative regional cerebral blood flow (rCBF) at rest was measured in 44 volunteers using both dynamic susceptibility contrast (DSC) MRI and (99m)Tc-HMPAO SPECT on the same day. METHOD: In MRI, a Gd-DTPA-BMA contrast agent bolus (0.3 mmol/kg body wt) was monitored with a simultaneous dual FLASH pulse sequence (time resolution 1.5 s). MRI-based rCBF images were calculated by singular value decomposition-based deconvolution of the measured tissue concentration-time curve with an arterial input function from a small artery within the imaging slice. In the SPECT investigation, 900 MBq of (99m)Tc-HMPAO was injected intravenously. Relative rCBF in gray matter in the thalamus and in frontal white matter was determined. RESULTS: The ratio of relative rCBF in gray matter to relative rCBF in white matter was 2.21 +/- 0.57 using MRI and 2.24 +/- 0.54 using SPECT (mean +/- SD). CONCLUSION: Relative rCBF maps from DSC MRI and (99m)Tc-HMPAO SPECT showed good agreement, and the MRI-based rCBF ratio correlated with the corresponding SPECT-based ratio (r = 0.79, p < 0.0000006).

• Författare: Ronnie Wirestam; Erik Ryding; Arne Lindgren; Bo Geijer; Leif Ostergaard; Linda Knutsson; Stig Holtås; Freddy Ståhlberg
• Avdelning/ar: Medicinsk strålningsfysik, Lund; Klinisk neurofysiologi; Neurologi, Lund; Diagnostisk radiologi, Lund; MR Physics
• Publiceringsår: 2000
• Språk: Engelska
• Sidor: 526-530
• Publikation/Tidskrift/Serie: Journal of Computer Assisted Tomography
• Volym: 24
• Issue: 4
• Dokumenttyp: Artikel i tidskrift
• Förlag: Lippincott Williams & Wilkins
• Ämne: Neurology; Radiology, Nuclear Medicine and Medical Imaging
• Aktiv: Published
• Projekt: Optimisation and Validation of Dynamic Susceptibility Contrast MRI
• Forskningsgrupp: MR Physics
• ISBN/ISSN/Övrigt: ISSN: 1532-3145