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Ronnie Wirestam

Professor

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Combining Phase and Magnitude Information for Contrast Agent Quantification in Dynamic Contrast-Enhanced MRI Using Statistical Modeling

Författare

  • Patrik Brynolfsson
  • Jun Yu
  • Ronnie Wirestam
  • Mikael Karlsson
  • Anders Garpebring

Summary, in English

Purpose: The purpose of this study was to investigate, using simulations, a method for improved contrast agent (CA) quantification in DCE-MRI. Methods: We developed a maximum likelihood estimator that combines the phase signal in the DCE-MRI image series with an additional CA estimate, e.g. the estimate obtained from magnitude data. A number of simulations were performed to investigate the ability of the estimator to reduce bias and noise in CA estimates. Noise levels ranging from that of a body coil to that of a dedicated head coil were investigated at both 1.5T and 3T. Results: Using the proposed method, the root mean squared error in the bolus peak was reduced from 2.24 to 0.11 mM in the vessels and 0.16 to 0.08 mM in the tumor rim for a noise level equivalent of a 12-channel head coil at 3T. No improvements were seen for tissues with small CA uptake, such as white matter. Conclusion: Phase information reduces errors in the estimated CA concentrations. A larger phase response from higher field strengths or higher CA concentrations yielded better results. Issues such as background phase drift need to be addressed before this method can be applied in vivo. (C) 2014 Wiley Periodicals, Inc.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2015

Språk

Engelska

Sidor

1156-1164

Publikation/Tidskrift/Serie

Magnetic Resonance in Medicine

Volym

74

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • inverse problem
  • phase
  • contrast agent quantification
  • dynamic contrast-enhanced MRI

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1522-2594