Comparison of MRImethods for measuringwhole-brain oxygen extraction fraction under different geometric conditions at 7T
Summary, in English
Methods: OEF estimates in 16 healthy subjects were obtained at 7T utilizing
susceptometry-based oximetry (SBO), quantitative susceptibility mapping (QSM), and transverse relaxation rate (R2*). Two major draining veins, that is, the superior sagittal sinus (SSS) and the straight sinus (SS), were investigated, including mutual agreement between the methods in each of the two different vessels, agreement between vessels as well as potential vessel angle and vessel size dependences.
Results: Very good correlation (r = .88) was found between SBO-based and QSM-based OEF estimates in SSS. Only QSM showed a moderate correlation (r = .61) between corresponding OEF estimates in SSS and SS. For SBO, a trend of increasing OEF estimates was observed as the SS vessel angle relative to the main magnetic field increased. No obvious size dependence could be established for anymethod. TheR2*-basedOEFestimates were reasonable (35%-36%), but the observed range was somewhat low.
Conclusion: The results indicate thatQSMis a promising candidate for assessment of OEF estimates, for example, providing reasonably robust estimates across awide range of vessel orientations.
- MR Physics
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
Journal of Neuroimaging
Artikel i tidskrift
- Radiology, Nuclear Medicine and Medical Imaging
- Other Physics Topics
- Gradient echo-based quantitative MRI of human brain at 7T
- MR Physics
- ISSN: 1051-2284