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Ronnie Wirestam


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Tissue response curve shape analysis of dynamic glucose enhanced (DGE) and dynamic contrast enhanced (DCE) MRI in patients with brain tumor


  • Anina Seidemo
  • Ronnie Wirestam
  • Gunther Helms
  • Karin Markenroth bloch
  • Xiang Xu
  • Johan Bengzon
  • Pia C. Sundgren
  • Peter C. M. Van Zijl
  • Linda Knutsson

Summary, in English

Dynamic glucose enhanced (DGE) MRI is used to study the signal intensity time course (tissue response curve) after D-glucose injection. D-glucose has potential as a biodegradable alternative or complement to gadolinium-based contrast agents, with DGE being comparable to dynamic contrast enhanced (DCE) MRI. However, the tissue uptake kinetics as well as the detection methods of DGE differ from DCE, and it is relevant to compare these techniques in terms of spatiotemporal enhancement patterns. This study aims to develop a DGE analysis method based on tissue response curve shapes, and to investigate whether DGE MRI provides similar or complementary information to DCE MRI. Eleven patients with suspected gliomas were studied. Tissue response curves were measured for DGE and DCE MRI at 7 tesla and the area under curve (AUC) was assessed. Seven types of response curve shapes were postulated and subsequently identified by deep learning to create color-coded “curve maps” showing the spatial distribution of different curve types. DGE AUC values were significantly higher in lesions than in normal tissue (p


  • MR Physics
  • Medicinsk strålningsfysik, Lund
  • Diagnostisk radiologi, Lund
  • Lund University Bioimaging Center
  • LUCC: Lunds universitets cancercentrum
  • Neurokirurgi
  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • Neuroradiologi
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease






NMR in Biomedicine


Artikel i tidskrift


John Wiley & Sons Inc.


  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics




  • MR Physics
  • Neuroradiology


  • ISSN: 0952-3480