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Ronnie Wirestam

Professor

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In vivo visualization of displacement-distribution-derived parameters in q-space imaging.

Författare

  • Jimmy Lätt
  • Markus Nilsson
  • Ronnie Wirestam
  • Edvin Johansson
  • Elna-Marie Larsson
  • Freddy Ståhlberg
  • Sara Brockstedt

Summary, in English

Objective



This study aimed to explore the potential of in vivo q-space imaging in the differentiation between different cerebral water components.

Materials and Methods



Diffusion-weighted imaging was performed in six directions with 32 equally spaced q values and a maximum b value of 6600 s/mm2. The shape of the signal-attenuation curve and the displacement propagator were examined and compared with a normal distribution using the kurtosis parameter. Maps displaying kurtosis, fast and slow components of the apparent diffusion coefficients, fractional anisotropy and directional diffusion were calculated. The displacement propagator was further described by the full width at half and at tenth maximum and by the probability density of zero displacement P(0). Three healthy volunteers and three patients with previously diagnosed multiple sclerosis (MS) were examined.

Results



Simulations indicated that the kurtosis of a signal-attenuation curve can determine if more than one water component is present and that care must be taken to select an appropriate threshold. It was possible to distinguish MS plaques in both signal and diffusional kurtosis maps, and in one patient, plaques of different degree of demyelinization showed different behavior.

Discussion



Our results indicate that in vivo q-space analysis is a potential tool for the assessment of different cerebral water components, and it might extend the diagnostic interpretation of data from diffusion magnetic resonance imaging.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • MR Physics
  • Diagnostisk radiologi, Lund

Publiceringsår

2008

Språk

Engelska

Sidor

77-87

Publikation/Tidskrift/Serie

Magnetic Resonance Imaging

Volym

26

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Forskningsgrupp

  • MR Physics

ISBN/ISSN/Övrigt

  • ISSN: 1873-5894