Tommy Knöös
Sjukhusfysiker
Development of dosimetric procedures for experimental ultra-high dose rate irradiation at a clinical linear accelerator
Författare
Summary, in English
As radiotherapy using ultra-high dose rates has gained new interest, the dosimetric challenges arising at these conditions needs to be addressed. Ionization chambers suffer from a large decrease in ion collection efficiency due to ion recombination, making on-line dosimetry difficult. In this work we present experimental setups and dosimetric procedures for FLASH irradiation of cells, zebrafish embryos and small animals using a 10 MeV electron beam at a modified clinical linear accelerator, and describe the dosimetric steps required to initiate clinical trials. The dosimetric equipment used for our pre-clinical experiments consisted of radiochromic film, thermoluminescent dosimeters, a Farmer-type ionization chamber and phantom material mimicking the experimental setup for irradiation. In preparation for small animal irradiation, dose profiles and depth dose curves were measured for all collimator sizes. The average dose rates were ≥620 Gy/s, ≥640 Gy/s and ≥400 Gy/s for cells, zebrafish embryos and small animals, respectively.
Avdelning/ar
- Medicinsk strålningsfysik, Lund
- Radiotherapy Physics
- Systemisk strålterapi
- LUCC: Lunds universitets cancercentrum
- Medicinsk strålningsfysik, Malmö
Publiceringsår
2022-01
Språk
Engelska
Publikation/Tidskrift/Serie
Journal of Physics: Conference Series
Volym
2167
Länkar
Dokumenttyp
Konferensbidrag
Förlag
IOP Publishing
Ämne
- Cancer and Oncology
- Radiology, Nuclear Medicine and Medical Imaging
- Other Physics Topics
Conference name
11th International Conference on 3D Radiation Dosimetry, IC3DDose 2021
Conference date
2021-06-15
Conference place
Quebec City, Virtual, Canada
Status
Published
Forskningsgrupp
- Radiotherapy Physics
- Medical Radiation Physics, Malmö