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X-ray Phase-contrast imaging

Martin Bech

Universitetslektor

X-ray Phase-contrast imaging

Preclinical x-ray dark-field radiography for pulmonary emphysema evaluation

Författare

  • A. Yaroshenko
  • F. G. Meinel
  • M. Bech
  • A. Tapfer
  • A. Velroyen
  • S. Schleede
  • M. Muller
  • S. Auweter
  • A. Bohla
  • A. O. Yildirim
  • K. Nikolaou
  • F. Bamberg
  • O. Eickelberg
  • M. Reiser
  • F. Pfeiffer
Visa allt

Summary, in English

Pulmonary emphysema is a widespread disorder characterized by irreversible destruction of alveolar walls. The spatial distribution of the disease, so far, could only be obtained using an x-ray CT scan, implying a high patient dose. X-ray scattering on alveolar structures is measured in the dark-field signal. The signal is dependent on the size of alveoli and therefore, a combination of absorption and dark-field signal is explored for mapping the distribution of emphysema in the lung on x-ray projection images. In this study three excised murine lungs with pulmonary emphysema and three control samples were imaged using a compact, cone-beam, small-animal x-ray dark-field scanner with a polychromatic source. Statistical analysis of the results, based on a combination of transmission and dark-field signals, revealed a distinct difference between emphysematous and control samples. Subsequently, the distribution of emphysema was mapped out per-pixel for the lungs and showed good agreement with histological findings.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2013

Språk

Engelska

Sidor

370-373

Publikation/Tidskrift/Serie

Proceedings - International Symposium on Biomedical Imaging

Dokumenttyp

Konferensbidrag

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • dark-field
  • emphysema
  • grating interferometer
  • phase-contrast
  • x-ray

Conference name

2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013

Conference date

2013-04-07 - 2013-04-11

Conference place

San Francisco, CA, United States

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1945-7928
  • ISSN: 1945-8452
  • ISBN: 978-1-4673-6455-3
  • ISBN: 978-1-4673-6456-0