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Bo-Anders Jönsson

Professor

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Survival of mammalian cells exposed to ultrahigh dose rates from a laser-produced plasma x-ray source

Författare

  • Carl Tillman
  • Gustav Grafström
  • Ann-Charlotte Jonsson
  • Bo-Anders Jönsson
  • Ian Mercer
  • Sören Mattsson
  • Sven-Erik Strand
  • Sune Svanberg

Summary, in English

PURPOSE: To determine whether intense laser-produced x rays have an increased radiation hazard. MATERIALS AND METHODS: Mammalian cells were exposed to x rays from a laser-produced plasma that produced ultrahigh peak absorbed dose rates, up to a factor of 10(10) higher than those produced by conventional x rays used in imaging. The cell survival was studied as a function of the absorbed dose. The survival of mammalian cells exposed to high peak absorbed dose rates with laser-produced x rays was compared with the survival of cells exposed to standard absorbed dose rates with conventional x-ray sources. Comparative survival studies were performed by using a conventional x-ray tube and a cobalt 60 source. The absorbed doses in the irradiation field were measured with thermoluminescent dosimeters. RESULTS: Cell survival following irradiation by filtered, laser-produced x rays with a high dose rate was not markedly different from the survival following irradiation by conventional sources. There was, however, a notable difference between the survival after exposure to filtered, laser-produced x rays and the survival after exposure to unfiltered laser-produced x rays. CONCLUSION: Exposure to filtered, laser-produced x rays with a high dose rate does not lead to increased harm to mammalian cells exposed in vitro compared with the harm from exposure to x rays from conventional sources, which indicates that the use of high-power laser facilities for medical imaging is justified

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • Medicinsk strålningsfysik, Malmö
  • Atomfysik

Publiceringsår

1999

Språk

Engelska

Sidor

860-865

Publikation/Tidskrift/Serie

Radiology

Volym

213

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Radiological Society of North America

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Aktiv

Published

Forskningsgrupp

  • Medical Radiation Physics, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1527-1315