Quantification of normal cerebral oxygen extraction and oxygen metabolism by phase-based MRI susceptometry: evaluation of repeatability using two different imaging protocols.

Summary, in English

Global oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) were quantified in a test-retest study. Cerebral blood flow (CBF) data, required for CMRO2 estimation, were obtained using dynamic susceptibility contrast MRI (DSC-MRI). OEF and CMRO2 were quantified using two separate data sets, that is, conventional high-resolution (HR) gradient echo (GRE) phase maps as well as echo planar imaging (EPI) phase maps taken from the baseline (precontrast) part of the DSC-MRI time series. The EPI phase data were included to elucidate whether an extra HR-GRE scan is needed to obtain information about OEF and CMRO2 , or if this information can be extracted from the DSC-MRI experiment only.

• Författare: Robin Kämpe; Emelie Lind; Freddy Ståhlberg; Danielle van Westen; Linda Knutsson; Ronnie Wirestam
• Avdelning/ar: MultiPark: Multidisciplinary research focused on Parkinson´s disease; Medicinsk strålningsfysik, Lund; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Diagnostisk radiologi, Lund; Neuroradiologi; MR Physics
• Publiceringsår: 2017
• Språk: Engelska
• Sidor: 220-2011
• Publikation/Tidskrift/Serie: Clinical Physiology and Functional Imaging
• Volym: 37
• Issue: 2
• Fulltext: - 1 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26490359?dopt=Abstract; http://dx.doi.org/10.1111/cpf.12288
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Radiology, Nuclear Medicine and Medical Imaging; Other Physics Topics
• Status: Published
• Forskningsgrupp: Neuroradiology; MR Physics
• ISBN/ISSN/Övrigt: ISSN: 1475-0961